Structure analysis

Binary structure of human DECR.

X-ray diffraction
2.2Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 37300 Å2
Buried surface area: 25600 Å2
Dissociation area: 5,700 Å2
Dissociation energy (ΔGdiss): 78 kcal/mol
Dissociation entropy (TΔSdiss): 16 kcal/mol
Interface energy (ΔGint): -138 kcal/mol
Symmetry number: 4

Macromolecules

Chains: A, B, C, D
Length: 302 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q16698 (Residues: 34-335; Coverage: 90%)
Gene names: DECR, DECR1, SDR18C1
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
SCOP: Tyrosine-dependent oxidoreductases

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