1w8d

X-ray diffraction
2.2Å resolution

Binary structure of human DECR.

Released:

Function and Biology Details

Reaction catalysed:
A (2E)-2-enoyl-CoA + NADP(+) = a (2E,4E)-2,4-dienoyl-CoA + NADPH
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 302 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q16698 (Residues: 34-335; Coverage: 90%)
Gene names: DECR, DECR1, SDR18C1
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 62.873Å b: 131.702Å c: 70.592Å
α: 90° β: 92.56° γ: 90°
R-values:
R R work R free
0.221 0.219 0.265
Expression system: Escherichia coli BL21