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Structure of human DECR ternary complex

Source organism: Homo sapiens
Biochemical function: NADPH binding
Biological process: positive regulation of cold-induced thermogenesis
Cellular component: catalytic complex

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EC 1.3.1.124: 2,4-dienoyl-CoA reductase ((3E)-enoyl-CoA-producing)

Reaction catalysed:
A (3E)-3-enoyl-CoA + NADP(+) = a (2E,4E)-2,4-dienoyl-CoA + NADPH
Systematic name:
(3E)-3-enoyl-CoA:NADP(+) 4-oxidoreductase
Alternative Name(s):
  • Delta(2),Delta(4)-dienoyl-CoA reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
The deposited structure of PDB entry 1w6u contains 4 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
The deposited structure of PDB entry 1w6u contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
The deposited structure of PDB entry 1w6u contains 4 copies of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial. Showing 1 copy in chain A.

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