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Crystal structure of 6-phosphogluconolactonase (TM1154) from Thermotoga maritima at 1.70A resolution

Source organism: Thermotoga maritima
Biochemical function: 6-phosphogluconolactonase activity
Biological process: pentose-phosphate shunt, oxidative branch
Cellular component: cytosol

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EC 3.1.1.31: 6-phosphogluconolactonase

Reaction catalysed:
6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate
Systematic name:
6-phospho-D-glucono-1,5-lactone lactonohydrolase
Alternative Name(s):
  • 6-PGL
  • Phosphogluconolactonase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01182
Domain description: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
Occurring in:
  1. 6-phosphogluconolactonase
The deposited structure of PDB entry 1vl1 contains 1 copy of Pfam domain PF01182 (Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase) in 6-phosphogluconolactonase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005900
Domain description: 6-phosphogluconolactonase, DevB-type
Occurring in:
  1. 6-phosphogluconolactonase
IPR039104
Domain description: 6-Phosphogluconolactonase
Occurring in:
  1. 6-phosphogluconolactonase
IPR006148
Domain description: Glucosamine/galactosamine-6-phosphate isomerase
Occurring in:
  1. 6-phosphogluconolactonase
IPR037171
Domain description: NagB/RpiA transferase-like
Occurring in:
  1. 6-phosphogluconolactonase

Structure domain

CATH CATH domain
3.40.50.1360
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. 6-phosphogluconolactonase
The deposited structure of PDB entry 1vl1 contains 1 copy of CATH domain 3.40.50.1360 (Rossmann fold) in 6-phosphogluconolactonase. Showing 1 copy in chain A.
SCOP SCOP annotation
52513
Class: Alpha and beta proteins (a/b)
Fold: NagB/RpiA/CoA transferase-like
Superfamily: NagB/RpiA/CoA transferase-like
Occurring in:
  1. 6-phosphogluconolactonase
The deposited structure of PDB entry 1vl1 contains 1 copy of SCOP domain 52513 (NagB-like) in 6-phosphogluconolactonase. Showing 1 copy in chain A.

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