› 1vkb

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
Epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187658 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-glutamylaminecyclotransferase Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q923B0 (Residues: 1-149; Coverage: 100%)
Gene names: A2ld1, Ggact
Sequence domains: Gamma-glutamyl cyclotransferase, AIG2-like
Structure domains: Gamma-glutamyl cyclotransferase-like

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P65
Unit cell:
a: 85.745Å b: 85.745Å c: 42.858Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.136 0.134 0.171
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Integrative, dynamic structural biology at atomic resolution--it's about time.
van den Bedem et al. (2015)
4 other articles

7 mentions without citation

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.
Kumar et al. (2012)
6 more