Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:
Structure analysis Details
Assemblies composition:
Assembly name:
Activation peptide fragment 2 and Hirudin-3A (preferred)
PDBe Complex ID:
PDB-CPX-133166 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Thrombin light chain
Molecule details ›
Chains: L, M
Length: 49 amino acids
Theoretical weight: 5.74 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Thrombin light chain
Length: 49 amino acids
Theoretical weight: 5.74 KDa
Source organism: Bos taurus
UniProt:
- Canonical:
P00735 (Residues: 318-366; Coverage: 8%)
Sequence domains: Thrombin light chain
Thrombin heavy chain
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P00735 (Residues: 367-625; Coverage: 43%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Hirudin-3A
Molecule details ›
Chains: I, J
Length: 15 amino acids
Theoretical weight: 1.84 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
Length: 15 amino acids
Theoretical weight: 1.84 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
- Canonical: P28507 (Residues: 51-65; Coverage: 23%)
Thrombin heavy chain
Molecule details ›
Chain: F
Length: 150 amino acids
Theoretical weight: 17.53 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 150 amino acids
Theoretical weight: 17.53 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P00735 (Residues: 367-516; Coverage: 25%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Thrombin heavy chain
Molecule details ›
Chain: G
Length: 109 amino acids
Theoretical weight: 12.27 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 109 amino acids
Theoretical weight: 12.27 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P00735 (Residues: 517-625; Coverage: 18%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
