X-ray diffraction
1.9Å resolution

Crystal structure of a cyclase subunit of imidazolglycerolphosphate synthase

Source organism: Thermotoga maritima
Entry author: Structural GenomiX

Function and Biology Details

Reaction catalysed:
(1a) L-glutamine + H(2)O = L-glutamate + NH(3)
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Imidazole glycerol phosphate synthase subunit HisF Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.11 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
  • Canonical: Q9X0C6 (Residues: 2-253; Coverage: 100%)
Gene names: TM_1036, hisF
Sequence domains: Histidine biosynthesis protein
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P6122
Unit cell:
a: 96.647Å b: 96.647Å c: 154.739Å
α: 90° β: 90° γ: 120°
R R work R free
0.202 0.202 0.224
Expression system: Escherichia coli