› 1vfp

X-ray diffraction
2.9Å resolution

Crystal structure of the SR CA2+-ATPase with bound AMPPCP

Released:
DOI: 10.2210/pdb1vfp/pdb
PDB entry 1vfp coloured by chain, front view.
PDB entry 1vfp coloured by chain, side view.
PDB entry 1vfp coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structure of the calcium pump with a bound ATP analogue.
Toyoshima C, Mizutani T
Nature 430 529-35 (2004)
PMID: 15229613

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137506 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 994 amino acids
Theoretical weight: 109.6 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P04191 (Residues: 1-993; Coverage: 99%)
Gene name: ATP2A1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand MG 2 x MG
Ligand ACP 2 x ACP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 90.92Å b: 123.62Å c: 151.82Å
α: 90° β: 107.21° γ: 90°
R-values:
R R work R free
0.256 0.247 0.287

Quick links

Citations

53 review citations

P-type ATPases.
Palmgren et al. (2011)
52 more

27 mentions without citation

Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from Alismatis Rhizoma.
Bailly C. (2022)
26 more