1v7p

X-ray diffraction
1.9Å resolution

Structure of EMS16-alpha2-I domain complex

Released:
Primary publication:
Crystal structure of EMS16 in complex with the integrin alpha2-I domain.
J. Mol. Biol. 341 519-27 (2004)
PMID: 15276841

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Snaclec EMS16 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.89 KDa
Source organism: Echis multisquamatus
UniProt:
  • Canonical: Q7T2Q1 (Residues: 24-157; Coverage: 100%)
Structure domains: Mannose-Binding Protein A, subunit A
Snaclec EMS16 subunit beta Chain: B
Molecule details ›
Chain: B
Length: 128 amino acids
Theoretical weight: 15.12 KDa
Source organism: Echis multisquamatus
UniProt:
  • Canonical: Q7T2Q0 (Residues: 27-154; Coverage: 100%)
Structure domains: Mannose-Binding Protein A, subunit A
Integrin alpha-2 Chain: C
Molecule details ›
Chain: C
Length: 200 amino acids
Theoretical weight: 21.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P17301 (Residues: 167-366; Coverage: 17%)
Gene names: CD49B, ITGA2
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: C2
Unit cell:
a: 163.766Å b: 38.449Å c: 69.524Å
α: 90° β: 91.52° γ: 90°
R-values:
R R work R free
0.188 0.188 0.235
Expression system: Escherichia coli BL21(DE3)