› 1v6d

X-ray diffraction
1.9Å resolution

The crystal structure of the trypsin complex with synthetic heterochiral peptide

Released:
DOI: 10.2210/pdb1v6d/pdb
PDB 1v6d coloured by chain and viewed from the front.
PDB 1v6d coloured by chain and viewed from the side.
PDB 1v6d coloured by chain and viewed from the top.
Source organism: Sus scrofa
Primary publication:
Secondary binding site of trypsin: revealed by crystal structure of trypsin-peptide complex.
Shamaladevi N, Pattabhi V
J. Biomol. Struct. Dyn. 22 635-42 (2005)
PMID: 15842169

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Trypsin Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.49 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P00761 (Residues: 9-231; Coverage: 97%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
PD(AIB)L(AIB)LA Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 698 Da
Source organism: Sus scrofa
Expression system: Not provided

Ligands and Environments

4 bound ligands:
Ligand CA 1 x CA
Ligand ACT 1 x ACT
Ligand TBF 1 x TBF
Ligand NME 1 x NME
1 modified residue:
Ligand AIB 2 x AIB

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 46.93Å b: 53.719Å c: 77.473Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.155 0.153 0.178
Expression system: Not provided

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Citations

1 citations in other articles

Trypsin inhibition by a peptide hormone: crystal structure of trypsin-vasopressin complex.
Syed Ibrahim et al. (2005)