Function and Biology

Benzamidine in complex with bovine trypsin varinat X(SSAI)bT.D1

Source organism: Bos taurus
Biochemical function: serpin family protein binding
Biological process: digestion
Cellular component: serine protease inhibitor complex

EC 3.4.21.4: Trypsin

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Systematic name:
-
Alternative Name(s):
  • Alpha-trypsin
  • Beta-trypsin
  • Cocoonase
  • Parenzyme
  • Parenzymol
  • Pseudotrypsin
  • Sperm receptor hydrolase
  • Tripcellim
  • Tryptar
  • Tryptase
  • Trypure

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 1v2u contains 1 copy of Pfam domain PF00089 (Trypsin) in Serine protease 1. Showing 1 copy in chain A [auth T].

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Serine protease 1
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Serine protease 1
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Serine protease 1
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Serine protease 1
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Serine protease 1
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Serine protease 1

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 1v2u contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Serine protease 1. Showing 2 copies in chain A [auth T].
SCOP SCOP annotation
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 1v2u contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Serine protease 1. Showing 1 copy in chain A [auth T].