X-ray diffraction
2.2Å resolution

serum paraoxonase by directed evolution


Function and Biology Details

Reactions catalysed:
An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine
A phenyl acetate + H(2)O = a phenol + acetate
An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serum paraoxonase/arylesterase 1 Chain: A
Molecule details ›
Chain: A
Length: 355 amino acids
Theoretical weight: 39.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P27170 (Residues: 1-355; Coverage: 99%)
Gene names: PON, PON1
Sequence domains: Arylesterase
Structure domains: TolB, C-terminal domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P43212
Unit cell:
a: 98.44Å b: 98.44Å c: 139.17Å
α: 90° β: 90° γ: 90°
R R work R free
0.186 0.185 0.217
Expression system: Escherichia coli