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Acetyl-CoA carboxylase carboxyltransferase domain L1705I/V1967I mutant

Source organism: Saccharomyces cerevisiae
Biochemical function: ligase activity
Biological process: not assigned
Cellular component: not assigned

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EC 6.4.1.2: Acetyl-CoA carboxylase

Reaction catalysed:
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA
Systematic name:
Acetyl-CoA:hydrogencarbonate ligase (ADP-forming)
Alternative Name(s):
  • ACC1 (gene name)
  • Acetyl coenzyme A carboxylase
  • Acetyl-CoA:carbon-dioxide ligase (ADP-forming)
  • HFA1 (gene name)

EC 6.3.4.14: Biotin carboxylase

Reaction catalysed:
ATP + [biotin carboxyl-carrier protein]-biotin-N(6)-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N(6)-L-lysine
Systematic name:
[Biotin carboxyl-carrier protein]-biotin-N(6)-L-lysine:hydrogencarbonate ligase (ADP-forming)
Alternative Name(s):
  • AccC (gene name)
  • Biotin carboxylase (component of acetyl CoA carboxylase)
  • Biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01039
Domain description: Carboxyl transferase domain
Occurring in:
  1. Acetyl-CoA carboxylase
The deposited structure of PDB entry 1uyv contains 3 copies of Pfam domain PF01039 (Carboxyl transferase domain) in Acetyl-CoA carboxylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029045
Domain description: ClpP/crotonase-like domain superfamily
Occurring in:
  1. Acetyl-CoA carboxylase
IPR011763
Domain description: Acetyl-coenzyme A carboxyltransferase, C-terminal
Occurring in:
  1. Acetyl-CoA carboxylase
IPR034733
Domain description: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Occurring in:
  1. Acetyl-CoA carboxylase
IPR011762
Domain description: Acetyl-coenzyme A carboxyltransferase, N-terminal
Occurring in:
  1. Acetyl-CoA carboxylase

Structure domain

CATH CATH domain
3.90.226.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Homology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Occurring in:
  1. Acetyl-CoA carboxylase
The deposited structure of PDB entry 1uyv contains 6 copies of CATH domain 3.90.226.10 (2-enoyl-CoA Hydratase; Chain A, domain 1) in Acetyl-CoA carboxylase. Showing 2 copies in chain A.
SCOP SCOP annotation
89572
Class: Alpha and beta proteins (a/b)
Fold: ClpP/crotonase
Superfamily: ClpP/crotonase
Occurring in:
  1. Acetyl-CoA carboxylase
The deposited structure of PDB entry 1uyv contains 6 copies of SCOP domain 89572 (Biotin dependent carboxylase carboxyltransferase domain) in Acetyl-CoA carboxylase. Showing 2 copies in chain A.

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