1uyr

X-ray diffraction
2.5Å resolution

Acetyl-CoA Carboxylase Carboxyltransferase Domain in complex with inhibitor Diclofop

Released:

Function and Biology Details

Reactions catalysed:
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA
ATP + [biotin carboxyl-carrier protein]-biotin-N(6)-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N(6)-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-CoA carboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 737 amino acids
Theoretical weight: 83.44 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00955 (Residues: 1482-2218; Coverage: 33%)
Gene names: ABP2, ACC1, FAS3, MTR7, N3175, YNR016C
Sequence domains: Carboxyl transferase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3221
Unit cell:
a: 136.78Å b: 136.78Å c: 244.41Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 0.248
Expression system: Escherichia coli