› 1uwg

X-ray diffraction
2.79Å resolution

Molecular Mechanism of Enantioselective Proton Transfer to Carbon in Catalytic Antibody 14D9

Released:
DOI: 10.2210/pdb1uwg/pdb
PDB entry 1uwg coloured by chain, front view.
PDB entry 1uwg coloured by chain, side view.
PDB entry 1uwg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9.
Zheng L, Baumann U, Reymond JL
Proc Natl Acad Sci U S A 101 3387-92 (2004)
PMID: 14988504

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213099 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ANTIBODY 14D9 Chains: H, Y
Molecule details ›
Chains: H, Y
Length: 225 amino acids
Theoretical weight: 23.93 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins
ANTIBODY 14D9 Chains: L, X
Molecule details ›
Chains: L, X
Length: 213 amino acids
Theoretical weight: 23.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand KHA 2 x KHA
Ligand PO4 6 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 68.47Å b: 97.92Å c: 70.88Å
α: 90° β: 99.28° γ: 90°
R-values:
R R work R free
0.207 0.204 0.276
Expression system: Escherichia coli

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Citations

2 review citations

Microbial Enzyme Biotechnology to Reach Plastic Waste Circularity: Current Status, Problems and Perspectives.
Orlando et al. (2023)
1 more

2 mentions without citation

Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors.
Pavlovicz et al. (2011)
1 more