Function and Biology Details
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
ATP + H(2)O = ADP + phosphate
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
- not assigned
Structure analysis Details
Length: 143 amino acids
Theoretical weight: 16 KDa
Source organism: SARS coronavirus HKU-39849
Expression system: Escherichia coli
- Canonical: P0C6X7 (Residues: 4118-4230; Coverage: 2%)
Sequence domains: Coronavirus replicase NSP9
Structure domains: Replicase NSP9