› 1urm

X-ray diffraction
1.7Å resolution

HUMAN PEROXIREDOXIN 5, C47S MUTANT

Released:
DOI: 10.2210/pdb1urm/pdb
PDB entry 1urm coloured by chain, front view.
PDB entry 1urm coloured by chain, side view.
PDB entry 1urm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the C47S Mutant of Human Peroxiredoxin 5
Evrard C, Smeets A, Knoops B, Declercq JP
J. Chem. Cryst. 34 553- (2004)

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-5, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 18.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30044 (Residues: 54-214; Coverage: 75%)
Gene names: ACR1, PRDX5, SBBI10
Sequence domains: Redoxin
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand BEZ 1 x BEZ
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P41212
Unit cell:
a: 65.646Å b: 65.646Å c: 122.043Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.147 0.146 0.169
Expression system: Escherichia coli

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