› 1upv

X-ray diffraction
2.1Å resolution

Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a synthetic agonist

Released:
DOI: 10.2210/pdb1upv/pdb
PDB 1upv coloured by chain and viewed from the front.
PDB 1upv coloured by chain and viewed from the side.
PDB 1upv coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.
Hoerer S, Schmid A, Heckel A, Budzinski RM, Nar H
J. Mol. Biol. 334 853-61 (2003)
PMID: 14643652

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 29.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55055 (Residues: 203-460; Coverage: 56%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 444 1 x 444
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 141.8Å b: 43.2Å c: 51.8Å
α: 90° β: 105.8° γ: 90°
R-values:
R R work R free
0.215 0.215 0.274
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Liver X receptors at the intersection of lipid metabolism and atherogenesis.
Lee et al. (2015)
3 more

3 mentions without citation

Identification of novel liver X receptor activators by structure-based modeling.
von Grafenstein et al. (2012)
2 more