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BHMT from rat liver

X-ray diffraction
2.5Å resolution
PDB entry 1umy coloured by chain, front view.
PDB entry 1umy coloured by chain, side view.
PDB entry 1umy coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Betaine--homocysteine S-methyltransferase 1
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Multimeric state: homo tetramer
Accessible surface area: 55148.58 Å2
Buried surface area: 21043.42 Å2
Dissociation area: 3,372.05 Å2
Dissociation energy (ΔGdiss): 28.55 kcal/mol
Dissociation entropy (TΔSdiss): 15.88 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-126721

Macromolecules

Betaine--homocysteine S-methyltransferase 1
Chains: A, B, C, D
Length: 407 amino acids
Theoretical weight: 45.06 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O09171 (Residues: 1-407; Coverage: 100%)
Gene name: Bhmt
Pfam: Homocysteine S-methyltransferase
InterPro:
CATH: Homocysteine-binding-like domain
SCOP: Homocysteine S-methyltransferase
Betaine--homocysteine S-methyltransferase 1 in PDB entry 1umy, assembly 1, front view.
Betaine--homocysteine S-methyltransferase 1 in PDB entry 1umy, assembly 1, side view.
Betaine--homocysteine S-methyltransferase 1 in PDB entry 1umy, assembly 1, top view.
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