Function and Biology

Crystal structure of an acidic, non-myotoxic phospholipase A2 from the venom of Bothrops jararacussu

Source organism: Bothrops jararacussu
Biochemical function: toxin activity
Biological process: arachidonic acid secretion
Cellular component: extracellular region

EC 3.1.1.4: Phospholipase A(2)

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Systematic name:
Phosphatidylcholine 2-acylhydrolase
Alternative Name(s):
  • Lecithinase A
  • Phosphatidase
  • Phosphatidolipase
  • Phospholipase A
  • Phospholipase A2

Sequence family

Pfam Protein family (Pfam)
PF00068
Domain description: Phospholipase A2
Occurring in:
  1. Acidic phospholipase A2 BthA-1
The deposited structure of PDB entry 1umv contains 1 copy of Pfam domain PF00068 (Phospholipase A2) in Acidic phospholipase A2 BthA-1. Showing 1 copy in chain A [auth X].

InterPro InterPro annotations
IPR001211
Domain description: Phospholipase A2
Occurring in:
  1. Acidic phospholipase A2 BthA-1
IPR016090
Domain description: Phospholipase A2 domain
Occurring in:
  1. Acidic phospholipase A2 BthA-1
IPR036444
Domain description: Phospholipase A2 domain superfamily
Occurring in:
  1. Acidic phospholipase A2 BthA-1
IPR033112
Domain description: Phospholipase A2, aspartic acid active site
Occurring in:
  1. Acidic phospholipase A2 BthA-1
IPR033113
Domain description: Phospholipase A2, histidine active site
Occurring in:
  1. Acidic phospholipase A2 BthA-1

Structure domain

CATH CATH domain
1.20.90.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Phospholipase A2
Homology: Phospholipase A2 domain
Occurring in:
  1. Acidic phospholipase A2 BthA-1
The deposited structure of PDB entry 1umv contains 1 copy of CATH domain 1.20.90.10 (Phospholipase A2) in Acidic phospholipase A2 BthA-1. Showing 1 copy in chain A [auth X].
SCOP SCOP annotation
48623
Class: All alpha proteins
Fold: Phospholipase A2, PLA2
Superfamily: Phospholipase A2, PLA2
Occurring in:
  1. Acidic phospholipase A2 BthA-1
The deposited structure of PDB entry 1umv contains 1 copy of SCOP domain 48623 (Vertebrate phospholipase A2) in Acidic phospholipase A2 BthA-1. Showing 1 copy in chain A [auth X].