PDBe 1ulh

X-ray diffraction
2.31Å resolution

A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase

Released:

Function and Biology Details

Reaction catalysed:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T1-TrpRS Chains: A, B
Molecule details ›
Chains: A, B
Length: 390 amino acids
Theoretical weight: 44.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23381 (Residues: 82-471; Coverage: 83%)
Gene names: IFI53, WARS, WRS
Sequence domains: tRNA synthetases class I (W and Y)
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 136.025Å b: 96.606Å c: 98.319Å
α: 90° β: 130.26° γ: 90°
R-values:
R R work R free
0.275 0.241 0.292
Expression system: Escherichia coli BL21(DE3)