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Crystal structure of von Willebrand Factor A1 domain complexed with snake venom bitiscetin

X-ray diffraction
2.85Å resolution
PDB entry 1uex coloured by chain, front view.
PDB entry 1uex coloured by chain, side view.
PDB entry 1uex coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 20134.62 Å2
Buried surface area: 5032.24 Å2
Dissociation area: 874.6 Å2
Dissociation energy (ΔGdiss): -3.51 kcal/mol
Dissociation entropy (TΔSdiss): 12.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137569

Macromolecules

Snaclec bitiscetin subunit alpha
Chain: A
Length: 131 amino acids
Theoretical weight: 14.95 KDa
Source organism: Bitis arietans
UniProt:
  • Canonical: Q7LZK5 (Residues: 1-131; Coverage: 100%)
Pfam: Lectin C-type domain
InterPro:
CATH: Mannose-Binding Protein A, subunit A
SCOP: C-type lectin domain
Snaclec bitiscetin subunit alpha in PDB entry 1uex, assembly 1, front view.
Snaclec bitiscetin subunit alpha in PDB entry 1uex, assembly 1, side view.
Snaclec bitiscetin subunit alpha in PDB entry 1uex, assembly 1, top view.
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Snaclec bitiscetin subunit beta
Chain: B
Length: 125 amino acids
Theoretical weight: 14.82 KDa
Source organism: Bitis arietans
UniProt:
  • Canonical: Q7LZK8 (Residues: 1-125; Coverage: 100%)
Pfam: Lectin C-type domain
InterPro:
CATH: Mannose-Binding Protein A, subunit A
SCOP: C-type lectin domain
Snaclec bitiscetin subunit beta in PDB entry 1uex, assembly 1, front view.
Snaclec bitiscetin subunit beta in PDB entry 1uex, assembly 1, side view.
Snaclec bitiscetin subunit beta in PDB entry 1uex, assembly 1, top view.
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von Willebrand factor
Chain: C
Length: 209 amino acids
Theoretical weight: 23.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04275 (Residues: 1260-1468; Coverage: 8%)
Gene names: F8VWF, VWF
Pfam: von Willebrand factor type A domain
InterPro:
CATH: von Willebrand factor, type A domain
SCOP: Integrin A (or I) domain
von Willebrand factor in PDB entry 1uex, assembly 1, front view.
von Willebrand factor in PDB entry 1uex, assembly 1, side view.
von Willebrand factor in PDB entry 1uex, assembly 1, top view.
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