PDBe 1udt

X-ray diffraction
2.3Å resolution

Crystal structure of Human Phosphodiesterase 5 complexed with Sildenafil(Viagra)


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
cGMP-specific 3',5'-cyclic phosphodiesterase Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 37.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O76074 (Residues: 537-860; Coverage: 37%)
Gene names: PDE5, PDE5A
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: C2221
Unit cell:
a: 60.122Å b: 155.632Å c: 89.896Å
α: 90° β: 90° γ: 90°
R R work R free
0.228 0.193 0.251
Expression system: Escherichia coli