Structure analysis

Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex

X-ray diffraction
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, C
Length: 198 amino acids
Theoretical weight: 22.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15796 (Residues: 270-467; Coverage: 42%)
Gene names: MADH2, MADR2, SMAD2
Pfam: MH2 domain
InterPro:
CATH: Tumour Suppressor Smad4
SCOP: SMAD domain

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Chain: B
Length: 236 amino acids
Theoretical weight: 25.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13485 (Residues: 314-549; Coverage: 43%)
Gene names: DPC4, MADH4, SMAD4
Pfam: MH2 domain
InterPro:
CATH: Tumour Suppressor Smad4
SCOP: SMAD domain

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