› 1u1n

X-ray diffraction
2.1Å resolution

Crystal Structure of UP1 Complexed With d(TTAGGGTTA (PRN)GG); A Human Telomeric Repeat Containing Nebularine

Released:
DOI: 10.2210/pdb1u1n/pdb
PDB entry 1u1n coloured by chain, front view.
PDB entry 1u1n coloured by chain, side view.
PDB entry 1u1n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human UP1 as a model for understanding purine recognition in the family of proteins containing the RNA recognition motif (RRM).
Myers JC, Shamoo Y
J Mol Biol 342 743-56 (2004)
PMID: 15342234

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114672 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 196 amino acids
Theoretical weight: 22.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09651 (Residues: 1-196; Coverage: 53%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(PRN)P*GP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.44 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PRN 1 x PRN

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P43212
Unit cell:
a: 51.752Å b: 51.752Å c: 171.258Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.256
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

5 review citations

Sequence-specific binding of single-stranded RNA: is there a code for recognition?
Auweter et al. (2006)
4 more

3 mentions without citation

Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function.
Levengood et al. (2019)
2 more