X-ray diffraction
2.13Å resolution

Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Rho guanine nucleotide exchange factor 12 Chain: A
Molecule details ›
Chain: A
Length: 385 amino acids
Theoretical weight: 44.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9NZN5 (Residues: 766-1138; Coverage: 24%)
Gene names: ARHGEF12, KIAA0382, LARG
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: C2
Unit cell:
a: 193.606Å b: 45.859Å c: 74.73Å
α: 90° β: 107.49° γ: 90°
R R work R free
0.237 0.235 0.274
Expression system: Escherichia coli