1twq

X-ray diffraction
2.3Å resolution

Crystal structure of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with PGN analog muramyl tripeptide

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for peptidoglycan binding by peptidoglycan recognition proteins.
Proc. Natl. Acad. Sci. U.S.A. 101 17168-73 (2004)
PMID: 15572450

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidoglycan recognition protein 3 Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96LB9 (Residues: 177-341; Coverage: 51%)
Gene names: PGLYRP3, PGRPIA
Structure domains: Peptidoglycan recognition protein-like
muramyl tripeptide Chain: P
Molecule details ›
Chain: P
Length: 5 amino acids
Theoretical weight: 620 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3221
Unit cell:
a: 104.511Å b: 104.511Å c: 42.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 0.252
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided