› 1twq

X-ray diffraction
2.3Å resolution

Crystal structure of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with PGN analog muramyl tripeptide

Released:
DOI: 10.2210/pdb1twq/pdb
PDB 1twq coloured by chain and viewed from the front.
PDB 1twq coloured by chain and viewed from the side.
PDB 1twq coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural basis for peptidoglycan binding by peptidoglycan recognition proteins.
Guan R, Roychowdhury A, Ember B, Kumar S, Boons GJ, Mariuzza RA
Proc. Natl. Acad. Sci. U.S.A. 101 17168-73 (2004)
PMID: 15572450

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidoglycan recognition protein 3 Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96LB9 (Residues: 177-341; Coverage: 51%)
Gene names: PGLYRP3, PGRPIA
Structure domains: Peptidoglycan recognition protein-like
muramyl tripeptide Chain: P
Molecule details ›
Chain: P
Length: 5 amino acids
Theoretical weight: 620 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
1 modified residue:
Ligand GMA 1 x GMA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3221
Unit cell:
a: 104.511Å b: 104.511Å c: 42.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 0.252
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

12 review citations

Non-canonical roles of tRNAs and tRNA mimics in bacterial cell biology.
Katz et al. (2016)
11 more

4 mentions without citation

Structural basis for peptidoglycan binding by peptidoglycan recognition proteins.
Guan et al. (2004)
3 more