› 1tw4

X-ray diffraction
2Å resolution

Crystal Structure of Chicken Liver Basic Fatty Acid Binding Protein (Bile Acid Binding Protein) Complexed With Cholic Acid

Released:
DOI: 10.2210/pdb1tw4/pdb
PDB 1tw4 coloured by chain and viewed from the front.
PDB 1tw4 coloured by chain and viewed from the side.
PDB 1tw4 coloured by chain and viewed from the top.
Source organism: Gallus gallus
Primary publication:
Crystal structure of chicken liver basic fatty acid-binding protein complexed with cholic acid.
Nichesola D, Perduca M, Capaldi S, Carrizo ME, Righetti PG, Monaco HL
Biochemistry 43 14072-9 (2004)
PMID: 15518556

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, liver Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.1 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P80226 (Residues: 2-126; Coverage: 99%)
Gene name: FABP1
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand CHD 4 x CHD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P212121
Unit cell:
a: 60.31Å b: 63.41Å c: 77.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.216 0.257

Quick links

Citations

3 review citations

Structural and Dynamic Determinants of Molecular Recognition in Bile Acid-Binding Proteins.
Toke O. (2022)
2 more

6 mentions without citation

Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα.
Fang et al. (2012)
5 more