Structure analysis

Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a RRCVLL Peptide Derived from Cdc42 splice isoform-2

X-ray diffraction
2.9Å resolution
Source organism: Rattus norvegicus
Assembly composition:
Non-polymer only trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25300 Å2
Buried surface area: 8300 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -69 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25500 Å2
Buried surface area: 8500 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -81 kcal/mol
Symmetry number: 1
Assembly 3 (preferred)
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25600 Å2
Buried surface area: 8800 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -78 kcal/mol
Symmetry number: 1
Assembly 4
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25600 Å2
Buried surface area: 8500 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 17 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -81 kcal/mol
Symmetry number: 1
Assembly 5
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25600 Å2
Buried surface area: 8300 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 17 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -73 kcal/mol
Symmetry number: 1
Assembly 6
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25800 Å2
Buried surface area: 8400 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 15 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -69 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, C, E, G, I, K
Length: 377 amino acids
Theoretical weight: 44.1 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04631 (Residues: 1-377; Coverage: 100%)
Gene name: Fnta
Pfam: Protein prenyltransferase alpha subunit repeat
InterPro: Protein prenyltransferase, alpha subunit
CATH: Protein prenylyltransferase
SCOP: Protein prenylyltransferase

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Chains: B, D, F, H, J, L
Length: 377 amino acids
Theoretical weight: 42.47 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53610 (Residues: 1-377; Coverage: 100%)
Gene name: Pggt1b
Pfam: Prenyltransferase and squalene oxidase repeat
InterPro:
CATH: Glycosyltransferase
SCOP: Protein prenyltransferases

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