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Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a RRCVLL Peptide Derived from Cdc42 splice isoform-2

X-ray diffraction
2.9Å resolution
PDB 1tnz coloured by chain and viewed from the front.
PDB 1tnz coloured by chain and viewed from the side.
PDB 1tnz coloured by chain and viewed from the top.
Source organism: Rattus norvegicus
Assembly composition:
Non-polymer only trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25300 Å2
Buried surface area: 8300 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -69 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25500 Å2
Buried surface area: 8500 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -81 kcal/mol
Symmetry number: 1
Assembly 3 (preferred)
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25600 Å2
Buried surface area: 8800 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -78 kcal/mol
Symmetry number: 1
Assembly 4
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25600 Å2
Buried surface area: 8500 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 17 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -81 kcal/mol
Symmetry number: 1
Assembly 5
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25600 Å2
Buried surface area: 8300 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 17 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -73 kcal/mol
Symmetry number: 1
Assembly 6
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Multimeric state: Non-polymer only trimer
Accessible surface area: 25800 Å2
Buried surface area: 8400 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 15 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -69 kcal/mol
Symmetry number: 1

Macromolecules

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Chains: A, C, E, G, I, K
Length: 377 amino acids
Theoretical weight: 44.1 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04631 (Residues: 1-377; Coverage: 100%)
Gene name: Fnta
Pfam: Protein prenyltransferase alpha subunit repeat
InterPro: Protein prenyltransferase, alpha subunit
CATH: Protein prenylyltransferase
SCOP: Protein prenylyltransferase
PDB 1tnz contains 1 copy of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in assembly 3. This protein is highlighted and viewed from the front.
PDB 1tnz contains 1 copy of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in assembly 3. This protein is highlighted and viewed from the side.
PDB 1tnz contains 1 copy of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in assembly 3. This protein is highlighted and viewed from the top.
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Geranylgeranyl transferase type-1 subunit beta
Chains: B, D, F, H, J, L
Length: 377 amino acids
Theoretical weight: 42.47 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53610 (Residues: 1-377; Coverage: 100%)
Gene name: Pggt1b
Pfam: Prenyltransferase and squalene oxidase repeat
InterPro:
CATH: Glycosyltransferase
SCOP: Protein prenyltransferases
PDB 1tnz contains 1 copy of Geranylgeranyl transferase type-1 subunit beta in assembly 3. This protein is highlighted and viewed from the front.
PDB 1tnz contains 1 copy of Geranylgeranyl transferase type-1 subunit beta in assembly 3. This protein is highlighted and viewed from the side.
PDB 1tnz contains 1 copy of Geranylgeranyl transferase type-1 subunit beta in assembly 3. This protein is highlighted and viewed from the top.
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Cell division control protein 42 homolog (Cdc42)
Chains: M, N, O, P, Q, R
Length: 6 amino acids
Theoretical weight: 761 Da
PDB 1tnz contains 1 copy of Cell division control protein 42 homolog (Cdc42) in assembly 3. This protein is highlighted and viewed from the front.
PDB 1tnz contains 1 copy of Cell division control protein 42 homolog (Cdc42) in assembly 3. This protein is highlighted and viewed from the side.
PDB 1tnz contains 1 copy of Cell division control protein 42 homolog (Cdc42) in assembly 3. This protein is highlighted and viewed from the top.
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