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YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)

Source organism: Saccharomyces cerevisiae
Biochemical function: kinase activity
Biological process: nucleoside monophosphate phosphorylation
Cellular component: cytoplasm

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EC 2.7.4.9: dTMP kinase

Reaction catalysed:
ATP + dTMP = ADP + dTDP
Systematic name:
ATP:dTMP phosphotransferase
Alternative Name(s):
  • Deoxythymidine 5'-monophosphate kinase
  • TMPK
  • Thymidine 5'-monophosphate kinase
  • Thymidine monophosphate kinase
  • Thymidylate kinase
  • Thymidylate monophosphate kinase
  • Thymidylic acid kinase
  • Thymidylic kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02223
Domain description: Thymidylate kinase
Occurring in:
  1. Thymidylate kinase
The deposited structure of PDB entry 1tmk contains 2 copies of Pfam domain PF02223 (Thymidylate kinase) in Thymidylate kinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018094
Domain description: Thymidylate kinase
Occurring in:
  1. Thymidylate kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Thymidylate kinase
IPR018095
Domain description: Thymidylate kinase, conserved site
Occurring in:
  1. Thymidylate kinase
IPR039430
Domain description: Thymidylate kinase-like domain
Occurring in:
  1. Thymidylate kinase

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Thymidylate kinase
The deposited structure of PDB entry 1tmk contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Thymidylate kinase. Showing 1 copy in chain A.
SCOP SCOP annotation
52541
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Thymidylate kinase
The deposited structure of PDB entry 1tmk contains 2 copies of SCOP domain 52541 (Nucleotide and nucleoside kinases) in Thymidylate kinase. Showing 1 copy in chain A.

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