1tka

X-ray diffraction
2.7Å resolution

SPECIFICITY OF COENZYME BINDING IN THIAMIN DIPHOSPHATE DEPENDENT ENZYMES: CRYSTAL STRUCTURES OF YEAST TRANSKETOLASE IN COMPLEX WITH ANALOGS OF THIAMIN DIPHOSPHATE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transketolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 678 amino acids
Theoretical weight: 73.66 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Not provided
UniProt:
  • Canonical: P23254 (Residues: 3-680; Coverage: 100%)
Gene names: TKL1, YP9499.29C, YPR074C
Sequence domains: Transketolase, thiamine diphosphate binding domain
Structure domains:

Ligands and Environments


Cofactor: Ligand N3T 2 x N3T
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 76.3Å b: 113.3Å c: 160.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.158 not available
Expression system: Not provided