EC 4.3.2.10: Imidazole glycerol-phosphate synthase
Reaction catalysed:
(1a) L-glutamine + H(2)O = L-glutamate + NH(3)
Systematic name:
5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate-lyase (L-glutamine-hydrolyzing; 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide-forming)
Alternative Name(s):
- HIS7 (gene name)
- HisFH (gene names)
- IGP synthase
Protein family (Pfam)![The deposited structure of PDB entry 1thf contains 1 copy of Pfam domain PF00977 (Histidine biosynthesis protein) in Imidazole glycerol phosphate synthase subunit HisF. Showing 1 copy in chain A [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/1thf_1_D_Pfam_PF00977_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1thf</span> contains 1 copy of Pfam domain <span class='highlight'>PF00977 (Histidine biosynthesis protein)</span> in <span class='highlight'>Imidazole glycerol phosphate synthase subunit HisF</span>. Showing 1 copy in chain <span class='highlight'>A [auth D]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 1thf contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Imidazole glycerol phosphate synthase subunit HisF. Showing 1 copy in chain A [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/1thf_1_D_CATH_3.20.20.70_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1thf</span> contains 1 copy of CATH domain <span class='highlight'>3.20.20.70 (TIM Barrel)</span> in <span class='highlight'>Imidazole glycerol phosphate synthase subunit HisF</span>. Showing 1 copy in chain <span class='highlight'>A [auth D]</span>.")
SCOP annotation![The deposited structure of PDB entry 1thf contains 1 copy of SCOP domain 51367 (Histidine biosynthesis enzymes) in Imidazole glycerol phosphate synthase subunit HisF. Showing 1 copy in chain A [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/1thf_1_D_SCOP_51367_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1thf</span> contains 1 copy of SCOP domain <span class='highlight'>51367 (Histidine biosynthesis enzymes)</span> in <span class='highlight'>Imidazole glycerol phosphate synthase subunit HisF</span>. Showing 1 copy in chain <span class='highlight'>A [auth D]</span>.")