1tdb

X-ray diffraction
2.65Å resolution

STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE

Released:

Function and Biology Details

Reaction catalysed:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate synthase Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 36.53 KDa
Source organism: Lactobacillus casei
Expression system: Not provided
UniProt:
  • Canonical: P00469 (Residues: 1-315; Coverage: 100%)
Gene name: thyA
Structure domains: Thymidylate synthase/dCMP hydroxymethylase domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6122
Unit cell:
a: 78.8Å b: 78.8Å c: 243.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.21 not available
Expression system: Not provided