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Crystal Structure of Human HDAC8 complexed with MS-344

Source organism: Homo sapiens
Biochemical function: histone decrotonylase activity
Biological process: regulation of telomere maintenance
Cellular component: cytoplasm

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EC 3.5.1.98: Histone deacetylase

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Systematic name:
Histone amidohydrolase
Alternative Name(s):
  • HDAC

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00850
Domain description: Histone deacetylase domain
Occurring in:
  1. Histone deacetylase 8
The deposited structure of PDB entry 1t67 contains 1 copy of Pfam domain PF00850 (Histone deacetylase domain) in Histone deacetylase 8. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003084
Domain description: Histone deacetylase
Occurring in:
  1. Histone deacetylase 8
IPR000286
Domain description: Histone deacetylase family
Occurring in:
  1. Histone deacetylase 8
IPR023801
Domain description: Histone deacetylase domain
Occurring in:
  1. Histone deacetylase 8
IPR023696
Domain description: Ureohydrolase domain superfamily
Occurring in:
  1. Histone deacetylase 8
IPR037138
Domain description: Histone deacetylase domain superfamily
Occurring in:
  1. Histone deacetylase 8

Structure domain

CATH CATH domain
3.40.800.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Arginase; Chain A
Homology: Histone deacetylase domain
Occurring in:
  1. Histone deacetylase 8
The deposited structure of PDB entry 1t67 contains 1 copy of CATH domain 3.40.800.20 (Arginase; Chain A) in Histone deacetylase 8. Showing 1 copy in chain A.
SCOP SCOP annotation
52773
Class: Alpha and beta proteins (a/b)
Fold: Arginase/deacetylase
Superfamily: Arginase/deacetylase
Occurring in:
  1. Histone deacetylase 8
The deposited structure of PDB entry 1t67 contains 1 copy of SCOP domain 52773 (Histone deacetylase, HDAC) in Histone deacetylase 8. Showing 1 copy in chain A.

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