1t67

X-ray diffraction
2.31Å resolution

Crystal Structure of Human HDAC8 complexed with MS-344

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone deacetylase 8 Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 41.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BY41 (Residues: 1-377; Coverage: 100%)
Gene names: CDA07, HDAC8, HDACL1
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P3121
Unit cell:
a: 80.644Å b: 80.644Å c: 105.523Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.212 0.274
Expression system: Spodoptera frugiperda