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Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

X-ray diffraction
1.9Å resolution
PDB 1t49 coloured by chain and viewed from the front.
PDB 1t49 coloured by chain and viewed from the side.
PDB 1t49 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 13400 Å2
Buried surface area: 900 Å2
Dissociation area: 400 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -5 kcal/mol
Symmetry number: 1

Macromolecules

Tyrosine-protein phosphatase non-receptor type 1
Chain: A
Length: 298 amino acids
Theoretical weight: 34.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-298; Coverage: 69%)
Gene names: PTP1B, PTPN1
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
SCOP: Higher-molecular-weight phosphotyrosine protein phosphatases
PDB 1t49 contains 1 copy of Tyrosine-protein phosphatase non-receptor type 1 in assembly 1. This protein is highlighted and viewed from the front.
PDB 1t49 contains 1 copy of Tyrosine-protein phosphatase non-receptor type 1 in assembly 1. This protein is highlighted and viewed from the side.
PDB 1t49 contains 1 copy of Tyrosine-protein phosphatase non-receptor type 1 in assembly 1. This protein is highlighted and viewed from the top.
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