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Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP

X-ray diffraction
2.3Å resolution
PDB entry 1t3n coloured by chain, ensemble of 2 models, front view.
PDB entry 1t3n coloured by chain, ensemble of 2 models, side view.
PDB entry 1t3n coloured by chain, ensemble of 2 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase iota and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 39457.55 Å2
Buried surface area: 7669.73 Å2
Dissociation area: 1,351.1 Å2
Dissociation energy (ΔGdiss): 24.6 kcal/mol
Dissociation entropy (TΔSdiss): 14.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114630

Macromolecules

DNA polymerase iota
Chains: A, B
Length: 388 amino acids
Theoretical weight: 43.88 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9UNA4 (Residues: 52-439; Coverage: 52%)
Gene names: POLI, RAD30B
Pfam:
InterPro:
CATH:
SCOP:
DNA polymerase iota in PDB entry 1t3n, assembly 1, front view.
DNA polymerase iota in PDB entry 1t3n, assembly 1, side view.
DNA polymerase iota in PDB entry 1t3n, assembly 1, top view.
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DNA chain T
Name: Template DNA strand
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.19 KDa
Template DNA strand in PDB entry 1t3n, assembly 1, front view.
Template DNA strand in PDB entry 1t3n, assembly 1, side view.
Template DNA strand in PDB entry 1t3n, assembly 1, top view.
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DNA chain P
Name: Primer DNA strand
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 13 nucleotides
Theoretical weight: 4.05 KDa
Primer DNA strand in PDB entry 1t3n, assembly 1, front view.
Primer DNA strand in PDB entry 1t3n, assembly 1, side view.
Primer DNA strand in PDB entry 1t3n, assembly 1, top view.
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