1t34

X-ray diffraction
2.95Å resolution

ROTATION MECHANISM FOR TRANSMEMBRANE SIGNALING BY THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR

Released:

Function and Biology Details

Reaction catalysed:
GTP = 3',5'-cyclic GMP + diphosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Atrial natriuretic peptide receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 435 amino acids
Theoretical weight: 48.43 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P18910 (Residues: 29-463; Coverage: 42%)
Gene name: Npr1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold
Atriopeptin-1 Chain: H
Molecule details ›
Chain: H
Length: 21 amino acids
Theoretical weight: 2.22 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P01161 (Residues: 129-149; Coverage: 16%)
Gene name: Nppa

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P61
Unit cell:
a: 100.131Å b: 100.131Å c: 259.803Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.237 0.269
Expression systems:
  • Cricetulus griseus
  • Not provided