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Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3

X-ray diffraction
2.1Å resolution
PDB entry 1t08 coloured by chain, front view.
PDB entry 1t08 coloured by chain, side view.
PDB entry 1t08 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 25062.76 Å2
Buried surface area: 3070.76 Å2
Dissociation area: 634.83 Å2
Dissociation energy (ΔGdiss): -1.5 kcal/mol
Dissociation entropy (TΔSdiss): 10.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150341

Macromolecules

Catenin beta-1
Chain: A
Length: 519 amino acids
Theoretical weight: 56.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P35222 (Residues: 146-664; Coverage: 67%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Pfam: Armadillo/beta-catenin-like repeat
InterPro:
CATH: Leucine-rich Repeat Variant
SCOP: Armadillo repeat
Catenin beta-1 in PDB entry 1t08, assembly 1, front view.
Catenin beta-1 in PDB entry 1t08, assembly 1, side view.
Catenin beta-1 in PDB entry 1t08, assembly 1, top view.
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Beta-catenin-interacting protein 1
Chain: B
Length: 46 amino acids
Theoretical weight: 5.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9NSA3 (Residues: 8-53; Coverage: 57%)
Gene names: CTNNBIP1, ICAT
Pfam: Beta-catenin-interacting protein ICAT
InterPro:
CATH: Beta-catenin-interacting ICAT
SCOP: beta-catenin-interacting protein ICAT
Beta-catenin-interacting protein 1 in PDB entry 1t08, assembly 1, front view.
Beta-catenin-interacting protein 1 in PDB entry 1t08, assembly 1, side view.
Beta-catenin-interacting protein 1 in PDB entry 1t08, assembly 1, top view.
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Adenomatous polyposis coli protein
Chain: C
Length: 15 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P25054 (Residues: 1484-1498; Coverage: 1%)
Gene names: APC, DP2.5
Pfam: APC repeat
Adenomatous polyposis coli protein in PDB entry 1t08, assembly 1, front view.
Adenomatous polyposis coli protein in PDB entry 1t08, assembly 1, side view.
Adenomatous polyposis coli protein in PDB entry 1t08, assembly 1, top view.
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