1sq0

X-ray diffraction
2.6Å resolution

Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
von Willebrand factor Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 24.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04275 (Residues: 1259-1471; Coverage: 8%)
Gene names: F8VWF, VWF
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain
Glycocalicin Chain: B
Molecule details ›
Chain: B
Length: 288 amino acids
Theoretical weight: 32.08 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P07359 (Residues: 17-304; Coverage: 45%)
Gene name: GP1BA
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 72.497Å b: 116.104Å c: 67.962Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.239
Expression systems:
  • Escherichia coli BL21(DE3)
  • Cricetulus griseus