› 1sny

X-ray diffraction
1.75Å resolution

Carbonyl reductase Sniffer of D. melanogaster

Released:
DOI: 10.2210/pdb1sny/pdb
PDB 1sny coloured by chain and viewed from the front.
PDB 1sny coloured by chain and viewed from the side.
PDB 1sny coloured by chain and viewed from the top.
Source organism: Drosophila melanogaster
Primary publication:
Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster.
Sgraja T, Ulschmid J, Becker K, Schneuwly S, Klebe G, Reuter K, Heine A
J. Mol. Biol. 342 1613-24 (2004)
PMID: 15364585

Function and Biology Details

Reaction catalysed: 
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sniffer, isoform A Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 29.04 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9W3H4 (Residues: 1-247; Coverage: 100%)
Gene names: CG10964, Dmel\CG10964, Dmel_CG10964, SNI, Sni, anon-WO03040301.183, sni
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 1 x NAP
No bound ligands
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: I222
Unit cell:
a: 71.7Å b: 73.9Å c: 92.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.247 0.284
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Virtual screening applications in short-chain dehydrogenase/reductase research.
Beck et al. (2017)
2 more

2 mentions without citation

Assisted assignment of ligands corresponding to unknown electron density.
Binkowski et al. (2010)
1 more