Structure analysis

Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization

X-ray diffraction
2.4Å resolution
Source organism: Canis lupus familiaris
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 34100 Å2
Buried surface area: 3600 Å2
Dissociation area: 1,800 Å2
Dissociation energy (ΔGdiss): 20 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -28 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B
Length: 350 amino acids
Theoretical weight: 40.75 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli
UniProt:
  • Canonical: P12637 (Residues: 22-371; Coverage: 90%)
Gene name: CASQ2
InterPro:
CATH: Glutaredoxin

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