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ALA 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B

Source organisms:
Biochemical function: serine-type endopeptidase inhibitor activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.81: Streptogrisin B

Reaction catalysed:
Hydrolysis of proteins with trypsin-like specificity.
Alternative Name(s):
  • Pronase B
  • Pronase enzyme B
  • SGPB
  • Serine proteinase B
  • Streptomyces griseus protease B
  • Streptomyces griseus proteinase 1
  • Streptomyces griseus proteinase B
  • Streptomyces griseus serine proteinase B
  • Streptomyces protease B

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00050
Domain description: Kazal-type serine protease inhibitor domain
Occurring in:
  1. Ovomucoid
The deposited structure of PDB entry 1sgp contains 1 copy of Pfam domain PF00050 (Kazal-type serine protease inhibitor domain) in Ovomucoid. Showing 1 copy in chain B [auth I].

PF00089
Domain description: Trypsin
Occurring in:
  1. Streptogrisin-B
The deposited structure of PDB entry 1sgp contains 1 copy of Pfam domain PF00089 (Trypsin) in Streptogrisin-B. Showing 1 copy in chain A [auth E].

InterPro InterPro annotations
IPR001316
Domain description: Peptidase S1A, streptogrisin
Occurring in:
  1. Streptogrisin-B
IPR002350
Domain description: Kazal domain
Occurring in:
  1. Ovomucoid
IPR001239
Domain description: Proteinase inhibitor I1, Kazal-type, metazoa
Occurring in:
  1. Ovomucoid
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Streptogrisin-B
IPR036058
Domain description: Kazal domain superfamily
Occurring in:
  1. Ovomucoid
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Streptogrisin-B
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Streptogrisin-B
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Streptogrisin-B
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Streptogrisin-B

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Streptogrisin-B
The deposited structure of PDB entry 1sgp contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Streptogrisin-B. Showing 2 copies in chain A [auth E].
3.30.60.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Ovomucoid
The deposited structure of PDB entry 1sgp contains 1 copy of CATH domain 3.30.60.30 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Ovomucoid. Showing 1 copy in chain B [auth I].
SCOP SCOP annotations
57468
Class: Small proteins
Fold: Kazal-type serine protease inhibitors
Superfamily: Kazal-type serine protease inhibitors
Occurring in:
  1. Ovomucoid
The deposited structure of PDB entry 1sgp contains 1 copy of SCOP domain 57468 (Ovomucoid domain III-like) in Ovomucoid. Showing 1 copy in chain B [auth I].
50495
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Streptogrisin-B
The deposited structure of PDB entry 1sgp contains 1 copy of SCOP domain 50495 (Prokaryotic proteases) in Streptogrisin-B. Showing 1 copy in chain A [auth E].

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