› › Function and Biology

2.4A Crystal structure of Staphylococcus aureus type I 3-dehydroquinase, with 3-dehydroquinate bound

Source organism: Staphylococcus aureus subsp. aureus MRSA252
Biochemical function: lyase activity
Biological process: 3,4-dihydroxybenzoate biosynthetic process
Cellular component: not assigned

Quick links

EC 4.2.1.10: 3-dehydroquinate dehydratase

Reaction catalysed:
3-dehydroquinate = 3-dehydroshikimate + H(2)O
Systematic name:
3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)
Alternative Name(s):
  • 3-dehydroquinase
  • 3-dehydroquinate hydro-lyase
  • 3-dehydroquinate hydrolase
  • 5-dehydroquinase
  • 5-dehydroquinate dehydratase
  • 5-dehydroquinate hydro-lyase
  • DHQase
  • Dehydroquinase
  • Dehydroquinate dehydratase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01487
Domain description: Type I 3-dehydroquinase
Occurring in:
  1. 3-dehydroquinate dehydratase
The deposited structure of PDB entry 1sfj contains 2 copies of Pfam domain PF01487 (Type I 3-dehydroquinase) in 3-dehydroquinate dehydratase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001381
Domain description: 3-dehydroquinate dehydratase type I
Occurring in:
  1. 3-dehydroquinate dehydratase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. 3-dehydroquinate dehydratase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. 3-dehydroquinate dehydratase
The deposited structure of PDB entry 1sfj contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in 3-dehydroquinate dehydratase. Showing 1 copy in chain B.
SCOP SCOP annotation
51570
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Occurring in:
  1. 3-dehydroquinate dehydratase
The deposited structure of PDB entry 1sfj contains 2 copies of SCOP domain 51570 (Class I aldolase) in 3-dehydroquinate dehydratase. Showing 1 copy in chain B.

Quick links