1sen

X-ray diffraction
1.2Å resolution

Endoplasmic reticulum protein Rp19 O95881

Released:

Function and Biology Details

Reaction catalysed:
2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein 12 Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95881 (Residues: 23-172; Coverage: 100%)
Gene names: TLP19, TXNDC12, UNQ713/PRO1376
Sequence domains: Thioredoxin-like
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 48.986Å b: 50.556Å c: 59.386Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.184
Expression system: Escherichia coli