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Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 4.2.1.119: Enoyl-CoA hydratase 2

Reaction catalysed:
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O
Systematic name:
(3R)-3-hydroxyacyl-CoA hydro-lyase
Alternative Name(s):
  • 2-enoyl-CoA hydratase 2
  • AtECH2
  • D-3-hydroxyacyl-CoA hydro-lyase
  • D-specific 2-trans-enoyl-CoA hydratase
  • ECH2
  • MFE-2
  • MaoC
  • PhaJAc

EC 4.2.1.107: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase

Reaction catalysed:
(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O
Systematic name:
(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA hydro-lyase ((24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA-forming)
Alternative Name(s):
  • (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA hydro-lyase
  • 46 kDa hydratase 2
  • D-3-hydroxyacyl-CoA dehydratase

EC 1.1.1.n12: (3R)-hydroxyacyl-CoA dehydrogenase

Reaction catalysed:
(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
Systematic name:
(R)-3-hydroxyacyl-CoA:NAD+ oxidoreductase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01575
Domain description: MaoC like domain
Occurring in:
  1. Enoyl-CoA hydratase 2
The deposited structure of PDB entry 1s9c contains 12 copies of Pfam domain PF01575 (MaoC like domain) in Enoyl-CoA hydratase 2. Showing 1 copy in chain G.

InterPro InterPro annotations
IPR029069
Domain description: HotDog domain superfamily
Occurring in:
  1. Enoyl-CoA hydratase 2
IPR002539
Domain description: MaoC-like dehydratase domain
Occurring in:
  1. Enoyl-CoA hydratase 2

Structure domain

CATH CATH domain
3.10.129.10
Class: Alpha Beta
Architecture: Roll
Topology: Thiol Ester Dehydrase; Chain A
Homology: Hotdog Thioesterase
Occurring in:
  1. Enoyl-CoA hydratase 2
The deposited structure of PDB entry 1s9c contains 24 copies of CATH domain 3.10.129.10 (Thiol Ester Dehydrase; Chain A) in Enoyl-CoA hydratase 2. Showing 2 copies in chain G.
SCOP SCOP annotation
82636
Class: Alpha and beta proteins (a+b)
Fold: Thioesterase/thiol ester dehydrase-isomerase
Superfamily: Thioesterase/thiol ester dehydrase-isomerase
Occurring in:
  1. Enoyl-CoA hydratase 2
The deposited structure of PDB entry 1s9c contains 24 copies of SCOP domain 82636 (MaoC-like) in Enoyl-CoA hydratase 2. Showing 2 copies in chain G.

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