Function and Biology

H98Q Mutant of Methylglyoxal Synthase from E. coli complexed with Phosphoglycolic Acid

Source organism: Escherichia coli
Biochemical function: lyase activity
Biological process: methylglyoxal biosynthetic process
Cellular component: cytosol

EC 4.2.3.3: Methylglyoxal synthase

Reaction catalysed:
Glycerone phosphate = methylglyoxal + phosphate
Systematic name:
Glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
Alternative Name(s):
  • Glycerone-phosphate phospho-lyase
  • Methylglyoxal synthetase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF02142
Domain description: MGS-like domain
Occurring in:
  1. Methylglyoxal synthase
1 copy of Pfam domain PF02142 (MGS-like domain) in Methylglyoxal synthase in PDB 1s8a.

InterPro InterPro annotations
IPR004363
Domain description: Methylglyoxal synthase
Occurring in:
  1. Methylglyoxal synthase
IPR011607
Domain description: Methylglyoxal synthase-like domain
Occurring in:
  1. Methylglyoxal synthase
IPR036914
Domain description: Methylglyoxal synthase-like domain superfamily
Occurring in:
  1. Methylglyoxal synthase

Structure domain

CATH CATH domain
3.40.50.1380
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Methylglyoxal synthase-like domain
Occurring in:
  1. Methylglyoxal synthase
1 copy of CATH domain 3.40.50.1380 (Rossmann fold) in Methylglyoxal synthase in PDB 1s8a.
SCOP SCOP annotation
52339
Class: Alpha and beta proteins (a/b)
Fold: Methylglyoxal synthase-like
Superfamily: Methylglyoxal synthase-like
Occurring in:
  1. Methylglyoxal synthase
1 copy of SCOP domain 52339 (Methylglyoxal synthase, MgsA) in Methylglyoxal synthase in PDB 1s8a.