› 1rvd

X-ray diffraction
1.9Å resolution

H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP

Released:
DOI: 10.2210/pdb1rvd/pdb
PDB entry 1rvd coloured by chain, front view.
PDB entry 1rvd coloured by chain, side view.
PDB entry 1rvd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Ahmadian MR, Zor T, Vogt D, Kabsch W, Selinger Z, Wittinghofer A, Scheffzek K
Proc Natl Acad Sci U S A 96 7065-70 (1999)
PMID: 10359839

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133956 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase HRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 18.92 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand DBG 1 x DBG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-18
Spacegroup: P3221
Unit cell:
a: 40.22Å b: 40.22Å c: 162.87Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.218 0.274
Expression system: Not provided

Quick links

Citations

23 review citations

Targeting RAS signalling pathways in cancer therapy.
Downward J. (2003)
22 more

3 mentions without citation

Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Ahmadian et al. (1999)
2 more