› 1ruu

Solution NMR

Solution structure of porcine peptide YY (pPYY) bound to DPC micelles

Released:
DOI: 10.2210/pdb1ruu/pdb
PDB entry 1ruu coloured by chain, ensemble of 20 models, front view.
PDB entry 1ruu coloured by chain, ensemble of 20 models, side view.
PDB entry 1ruu coloured by chain, ensemble of 20 models, top view.
Source organism: Sus scrofa
Primary publication:
Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors.
Lerch M, Mayrhofer M, Zerbe O
J Mol Biol 339 1153-68 (2004)
PMID: 15178255

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptide YY Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.25 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68005 (Residues: 1-36; Coverage: 100%)
Gene name: PYY
Sequence domains: Pancreatic hormone peptide

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Calculation of structure by torsion angle dynamics; refinement by energy minimization with full force-field in explicit water
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Neuropeptide Y Y2 receptor in health and disease.
Parker et al. (2008)
9 more

1 mention without citation

Non-specific binding and general cross-reactivity of Y receptor agonists are correlated and should importantly depend on their acidic sectors.
Parker et al. (2011)