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COMPLEX OF BENZAMIDINE WITH THE CATALYTIC DOMAIN OF HUMAN TWO CHAIN TISSUE PLASMINOGEN ACTIVATOR [(TC)-T-PA]

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.68: T-plasminogen activator

Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Systematic name:
-
Alternative Name(s):
  • Plasminogen activator, tissue-type
  • T-PA
  • Tissue plasminogen activator
  • Tissue-type plasminogen activator
  • tPA

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Tissue-type plasminogen activator chain B
The deposited structure of PDB entry 1rtf contains 1 copy of Pfam domain PF00089 (Trypsin) in Tissue-type plasminogen activator chain B. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Tissue-type plasminogen activator chain B
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Tissue-type plasminogen activator chain B
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Tissue-type plasminogen activator chain B
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Tissue-type plasminogen activator chain B
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Tissue-type plasminogen activator chain B
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Tissue-type plasminogen activator chain B

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Tissue-type plasminogen activator chain B
The deposited structure of PDB entry 1rtf contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Tissue-type plasminogen activator chain B. Showing 2 copies in chain B.
SCOP SCOP annotation
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. TWO CHAIN TISSUE PLASMINOGEN ACTIVATOR
  2. Tissue-type plasminogen activator chain B
The deposited structure of PDB entry 1rtf contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in TWO CHAIN TISSUE PLASMINOGEN ACTIVATOR. Showing 1 copy in chain A.

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